Recent Advancements of UF-Based Separation for Selective Enrichment of Proteins and Bioactive Peptides—A Review

Proteins are one of the primary building blocks that have significant functional properties to be applied in food and pharmaceutical industries. could beneficial their concentrated products or isolates, which membrane-based filtration methods such as ultrafiltration (UF) encompass application broad spectra protein sources. More importantly, selective enrichment by UF is immense interest due presence antinutrients may dominate perspicuous bioactivities. process primarily obstructed concentration polarization fouling; turn, a trade-off between productivity selectivity emerges, especially when pure isolates an ultimate goal. Several factors operating conditions membrane equipment leverage those pervasive contributions; therefore, protocols should optimized for each unique mixture mode configuration. For instance, employing charged membranes combining with electrodialysis enables efficient separation proteins similar molecular weight, hard achieve conventional membrane. Meanwhile, some proposed strategies, utilizing ultrasonic waves, tuning conditions, modifying surfaces, can effectively mitigate fouling issues. A plethora advancements UF, from material modification arrangement new configurations, contribute quest actualize promising potentials they reviewed this paper.